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Ganoderma 18 is a general tonic prescription, intended for those who suffer deficiencies of all basic essences (qi, blood, yin, yang), and who may have weakness of several or all organ systems. Such broadly defined patterns may arise from the impact of serious illness, side effects of toxic drug therapies, or debility with aging. However, one can use this formula as a general tonic without having to suffer from substantial health problems; for example, it can be taken to recover from stressful events, for weak immune functions leading to frequent infections, and for treating mild fatigue. The formula is based on the traditional Ginseng Nutritive Combination (Renshen Yangrong Tang), a formula with similar purpose. The unique feature of Ganoderma 18 is the addition of kidney essence tonics: ganoderma, the general tonic herb, with three yang tonics (eucommia, cistanche, epimedium) and three yin/blood tonics (ligustrum, ho-shou-wu, lycium fruit). Although ganoderma has been known and respected since ancient times, it was always quite rare and therefore not included in widely-used formulas until very recently, when cultivation methods had been developed. This formula is similar to the well-known patent remedy Gejie Dabu Wan (Gecko Great Tonifying Pills), with ganoderma replacing gecko. Unlike Composition-A, which is also aimed at nourishing all organ systems, this formula does not have a specific focus on immune-based disorders, but, instead, on physical debility, easy fatigue, and poor function of one or more internal organ systems.