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Isatis 6 was designed on the basis of modern Chinese research into anti-infection activities of herbs, especially virus-inhibiting actions. The active constituents are quite different among the six herbs, with potential for a broad spectrum of action. The herbs were selected for their lack of side effects. This formula has been taken by a large number of people in the U.S. without adverse reaction, even with prolonged daily used (several months) in persons displaying a pre-existing weak stomach/spleen syndrome. Sometimes, bitter toxin-clearing herbs are not so easily tolerated (as an example, gentiana can cause diarrhea after only a few days regular use). There are other anti-infection herb formulas that can be selected as alternatives to this one, such as Paris 7, Bidens 6, and Patrinia 7. Each of these formulas contains isatis (either the root or the leaf); both Bidens 6 and Isatis 6 contain hu-chang; both Patrinia 7 and Isatis 6 contain lonicera; both Paris 7 and Isatis 6 contain oldenlandia. These herbs are commonly applied to infections and other "toxic" disorders, including tumors, which is why they appear repeatedly in the formulas. The different formulations came from study of slightly different approaches to treatments, but the effects of these herbs are similar. Although anti-toxin herbs and tonic herbs are traditionally considered to be quite different, several of these herbs, including oldenlandia, hu-chang, lonicera, and andrographitis, have been shown to have immune enhancing activity, one of the actions expected from tonics. To boost the anti-infection therapy, consider adding Myrolea-B (White Tiger).